학술논문
Macromolecular Viral Entry Inhibitors as Broad‐Spectrum First‐Line Antivirals with Activity against SARS‐CoV‐2
Document Type
article
Author
Rüdiger Groß; Lívia Mesquita Dias Loiola; Leila Issmail; Nadja Uhlig; Valentina Eberlein; Carina Conzelmann; Lia‐Raluca Olari; Lena Rauch; Jan Lawrenz; Tatjana Weil; Janis A. Müller; Mateus Borba Cardoso; Andrea Gilg; Olivia Larsson; Urban Höglund; Sandra Axberg Pålsson; Anna Selch Tvilum; Kaja Borup Løvschall; Maria M. Kristensen; Anna‐Lena Spetz; Fortune Hontonnou; Marie Galloux; Thomas Grunwald; Alexander N. Zelikin; Jan Münch
Source
Advanced Science, Vol 9, Iss 20, Pp n/a-n/a (2022)
Subject
Language
English
ISSN
2198-3844
Abstract
Abstract Inhibitors of viral cell entry based on poly(styrene sulfonate) and its core–shell nanoformulations based on gold nanoparticles are investigated against a panel of viruses, including clinical isolates of SARS‐CoV‐2. Macromolecular inhibitors are shown to exhibit the highly sought‐after broad‐spectrum antiviral activity, which covers most analyzed enveloped viruses and all of the variants of concern for SARS‐CoV‐2 tested. The inhibitory activity is quantified in vitro in appropriate cell culture models and for respiratory viral pathogens (respiratory syncytial virus and SARS‐CoV‐2) in mice. Results of this study comprise a significant step along the translational path of macromolecular inhibitors of virus cell entry, specifically against enveloped respiratory viruses.