학술논문
NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model
Document Type
article
Author
Jennifer M. Peterson; David J. Wang; Vikram Shettigar; Steve R. Roof; Benjamin D. Canan; Nadine Bakkar; Jonathan Shintaku; Jin-Mo Gu; Sean C. Little; Nivedita M. Ratnam; Priya Londhe; Leina Lu; Christopher E. Gaw; Jennifer M. Petrosino; Sandya Liyanarachchi; Huating Wang; Paul M. L. Janssen; Jonathan P. Davis; Mark T. Ziolo; Sudarshana M. Sharma; Denis C. Guttridge
Source
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
The molecular mechanisms leading to heart failure in patients with Duchenne muscular dystrophy are unclear. Here the authors show that NF-κB is activated in the heart of dystrophin-deficient mice and that its ablation rescues cardiac function through chromatin remodeling and activation of gene expression.