학술논문
Disease Characteristics, Care-Seeking Behavior, and Outcomes Associated With the Use of AYUSH-64 in COVID-19 Patients in Home Isolation in India: A Community-Based Cross-Sectional Analysis
Document Type
article
Author
Narayanam Srikanth; Adarsh Kumar; Bhogavalli Chandrasekhararao; Richa Singhal; Babita Yadav; Shruti Khanduri; Sophia Jameela; Amit Kumar Rai; Arunabh Tripathi; Rakesh Rana; Azeem Ahmad; Bhagwan Sahai Sharma; Ankit Jaiswal; Rajesh Kotecha; State Level Collaborators; Tanuja Nesari; Mahesh Vyas; Umesh Tagade; Anup Thakar; Nilesh Bhatt; Kalpesh Dattani; Sagar Bhinde; Sanjeev Sharma; Pawan Kumar Godatwar; Nisha Ojha; H.M.L. Meena; Harish Bhakuni; Pradeep Kumar Goswami; Bishnu Choudhury; K Nishanth; AJV Sai Prasad; Sujata Dhoke; K Midhuna Mohan; Savita Gopod; Arvind Kumar; Ekta Dogra; G.K. Bora; K S Pravin; Pravin Masarom Radheshyam; P.L. Bharati; Jeuti Rani Das; Vimal Tewari; Deepika Tewari; Ritika Mishra; Kuldeep; D.S. Rotwar; Anil Ahvad; Sumed Paikrao; Amit Madan; Nandini Jadhav; Vikas Nariyal; Kavita Vyas; Anubha Chandla; Vineeta Negi; Chris Antony; Vipin Sharma; Poonam Mohod; Subhash Sharma; Meenakshi Suri; Aaditya Shah; G.V. Ramana; C Tejaswini; Raghavendra; S.K. Giri; Shashidhar Doddamani; M.N Shubhashree; Srinibash Sahoo; K.M. Pratap Shankar; Parvathy.G. Nair; Devi R Nair; V. Krishna Kumar; P.P. Pradeep Kumar; E Remya; A P Karthika; T.P Sinimol; P P Meghna; Praveen Balakrishnan; Emy.S. Surendran; Varsha Sumedhan; Amit Kumar; S.B. Singh; Neelam Singh; Anil Mangal; Deepa Sharma; Laxman Bhurke; Dattatray Dighe; Kuldeep Choudhary; Saylee Deshmukh; Sneha Marlewar; Shyam Kale; U.R. Shekhar Namboori; Savita Sharma; Priya Thakre; Prashant Shinde; Balaji Potbare; Deepak Rahangdale; Gwachung Magh; G.C. Bhuyan; P. Panda; K.K. Ratha; Krishna Rao; S Indu; A.K. Panda; Banamali Das; Susmita Ota; Rinku Tomar; Harbans Singh; Sandeep Baheti; Sanjeev Kumar; S Mahesh; Sangeeta Sangvikar; S.K. Vedi; Swati Sharma; V.B. Kumawat; Suhash Choudhary; Monika Kumari; P P Indu; Rahul D. Ghuse; Shriprakash; Shrawan Kumar Sahu; Ashok Kumar Sinha; P. Srinivas; K. Prameela Devi; S Asha; Sojeetra Niral; Karisma Singh; Kamble Pallavi; Ravi Ranjan Singh; Anjali B Prasad; Mayur Surana; Sanjay Kumar Singh; Harit Kumari; A.K. Srivastava; Tarun Kumar; Deepshikha Arya; D.S. Sahu; Tushar Kanti Mondal; L.D. Barik; Suparna Saha; Ranjita Ekka; Shakti Bhushan; Achintya Mitra; Saroj Kumar Debnath; Debajyoti Das; M Akashlal; A Abhayadev; Hemant Gupta; Ajay P Yadav; Asim Ali Khan; Munawar H Kazmi; Minhaj; Rahat Raza; Md.Nafees Khan; Md. Ishtiyaq Alam; Haseeb Alam Lari; N. Zaheer Ahmed; Hakimuddin Khan; Younis Iftikhar; Seema Akbar; Sheeren Afza; Mohammad Fazil; Ashok Kumar; Mohd Tarique; Amir Faisal Khan; Aijaz Ahmed; Anil Khurana; S. Karunakara Moorthi; Subhash Kaushik; Nitin Kumar Saklani; B. S. Rawat; Brunda Bezawada; Sunil Ramteke; A.K. Prusty; Liyi Karso; Amit Srivastav; Ratan Chandra Shil; Partha Pratim Pal; Lipipushpa Debata; G. Ravi Chandra Reddy; Sunil Prasad; Uttam Singh; Baidurjya Bhattacharjee; Santosh Kumar Tamang; Ravi kumar Sadarla; Pawan Sharma; Amulya Ratna Sahoo; Vibha; P Prasad; D. Karthikeyan; Raghvendra Rao; Surender Sandhu; Mohan Rao; HS Vadiraj; Ishwar V. Basavaraddi; Ishwar N Achary; K Satyalakshmi; Shivkesh; P. Yuvaraj Paul; Subhas Singh; Austin Jose; Robindra Teron; Imlikumba; Addul Wadud; Abdul Nasir Ansari; Tariq Nadeem Khan; Abdul Moheen; Tsewang Dolma; Tenzin Tenba; Anupam Srivastav; N. Ramakrishnan; Surendra Soni; Ram Shukla; Rohini Salve; M.N. Shaikh; Daxen Trivedi; Shital Bhagiya; Asha Patel; Anup Indoriya; Rachna Gandhi; Naresh Jain; Nirmal Chavada; Rahul Shingadiya; Nilesh Bhadraka; Nrupesh Gupta; Dilip Italiya; Piyush Shah; Maya Chaudhari; Sumit Patel; Bhavin Chaudhari; Mehul Parmar
Source
Frontiers in Public Health, Vol 10 (2022)
Subject
Language
English
ISSN
2296-2565
Abstract
BackgroundDuring the second wave of the COVID-19 pandemic in India, the Ministry of Ayush conducted a community study to provide therapeutic care to patients with asymptomatic, mild, and moderate COVID-19 in home isolation based on the empirical evidence generated on the efficacy of AYUSH-64 in COVID-19.ObjectiveTo document disease characteristics, care-seeking behavior, and outcomes in patients with asymptomatic, mild, or moderate COVID-19 in home isolation who used AYUSH-64 for COVID-19.MethodsCross-sectional analysis of the data generated through a community study conducted in India from 08 May to 31 August 2021 was performed to study the disease characteristics, care-seeking behavior during home isolation, clinical outcomes, adverse events, and the association between various risk factors and clinical recovery during the study period. The data were collected through semi-structured questionnaires, available in electronic data collection format at the baseline, 7, 14, and 21 days. A logistic regression was performed to explore the relationship between relevant variables and clinical recovery.ResultsData from 64,642 participants were analyzed for baseline assessment, and final analysis was done for 49,770 participants. The mean age of the enrolled participants was 38.8 ± 11.7 years, and 8.4% had co-morbidities. AYUSH-64 was utilized as an add-on to the standard care by 58.3% of participants. Comparable clinical outcomes were observed in participants utilizing AYUSH-64 either as a standalone or as an add-on to standard care, in terms of clinical recovery, disease progression, the requirement for oxygen supplementation, hospitalization, ICU admission, and need for ventilator support. Younger age, having no co-morbidities or substance abuse, and having been vaccinated were associated with early clinical recovery than those who were older and not vaccinated.ConclusionsThe study findings suggest that AYUSH-64 use, either standalone or as an adjunct to standard care, in asymptomatic, mild, or moderate COVID-19 is associated with good clinical outcomes. Ayush services and interventions can be effectively integrated into the mainstream public health architecture to serve public health goals.