학술논문
Management of Patients with Pancreatic Ductal Adenocarcinoma in the Real-Life Setting: Lessons from the French National Hospital Database
Document Type
article
Author
Christelle de la Fouchardière; Mustapha Adham; Anne-Marie Marion-Audibert; Antoine Duclos; Claude Darcha; Olivier Berthelet; Valérie Hervieu; Pascal Artru; Hélène Labrosse; Yohan Fayet; Bruno Ferroud-Plattet; Bruno Aublet-Cuvellier; Georges Chambon; Mathieu Baconnier; Christine Rebischung; Fadila Farsi; Isabelle Ray-Coquard; Charles Mastier; Pierre-Jean Ternamian; Nicolas Williet; Emmanuel Buc; Thomas Walter; Andrée-Laure Herr
Source
Cancers, Vol 13, Iss 14, p 3515 (2021)
Subject
Language
English
ISSN
2072-6694
Abstract
Pancreatic ductal adenocarcinoma (PDAC) remains a major public health challenge, and faces disparities and delays in the diagnosis and access to care. Our purposes were to describe the medical path of PDAC patients in the real-life setting and evaluate the overall survival at 1 year. We used the national hospital discharge summaries database system to analyze the management of patients with newly diagnosed PDAC over the year 2016 in Auvergne-Rhône-Alpes region (AuRA) (France). A total of 1872 patients met inclusion criteria corresponding to an incidence of 22.6 per 100,000 person-year. Within the follow-up period, 353 (18.9%) were operated with a curative intent, 743 (39.7%) underwent chemo- and/or radiotherapy, and 776 (41.4%) did not receive any of these treatments. Less than half of patients were operated in a high-volume center, defined by more than 20 PDAC resections performed annually, mainly university hospitals. The 1-year survival rate was 47% in the overall population. This study highlights that a significant number of patients with PDAC are still operated in low-volume centers or do not receive any specific oncological treatment. A detailed analysis of the medical pathways is necessary in order to identify the medical and territorial determinants and their impact on the patient’s outcome.