학술논문

Surgical outcomes of gallbladder cancer: the OMEGA retrospective, multicentre, international cohort studyResearch in context
Document Type
article
Author
Anita BalakrishnanPetros BarmpounakisNikolaos DemirisAsif JahHarry V.M. SpiersShibojit TalukderJack L. MartinPaul GibbsSimon J.F. HarperEmmanuel L. HuguetVasilis KosmoliaptsisSiong S. LiauRaaj K. PraseedomBristi BasuXavier de AretxabalaJavier LendoireShishir MaithelAlejandro BranesBodil AnderssonAlejandro SerrabloVolkan AdsayTomoyuki AbeMoh'd Abu HilalMaria del Mar Achalandabaso BoiraMustapha AdhamMohamed AdamMaryam AhmadBilal Al-SarirehMaite AlbiolNassir AlhaboobAdnan AlseidiHoussem AmmarAkshay AnandPantelis AntonakisVeronica ArayaStanley W. AshleyGeorgi AtanasovFabio AusaniaRicardo BalestriAbhirup BanerjeeSimon BantingGiedrius BarauskasFabian BartschAndrea BelliSimona BerettaFrederik BerrevoetGerardo Blanco FernandezLouisa BolmMathieu BonalEmre BozkurtAndries E. BraatLuke BradshawLyle BurdineMatthew ByrneMaria CaceresMaria Jesus Castro SantiagoBenjamin ChanLynn ChongAhmet ÇokerMaria Conde RodriguezDaniel CroaghAlyn CrutchleyCarmen CutoloMathieu D'HondtDaniel D'SouzaFreek DaamsRaffaele Dalla ValleJosé DavideMario de BellisMarieke de BoerCeline de MeyerePhilip de ReuverMatthew DixonPanagiotis DorovinisGabriela Echeverría BauerMaria EduardaHasan EkerJoris ErdmannMert ErkanEvangelos FelekourasEmanuele FelliEduardo FernandesEduardo Figueroa RiveraAndras FulopDaniel GalunMichael GerhardsPoya GhorbaniFabio GiannoneLuis GilEmmanouil GiorgakisMario GiuffridaFelice GiulianteIoannis GkekasMiguel Gomez BravoBas Groot KoerkampOscar GuevaraAlfredo GuglielmiAiste GullaRahul GuptaAmit GuptaMarta GutiérrezAbu Bakar Hafeez BhattiJeroen HagendoornZain HajeeAbdul Rahman HakeemHytham HamidSayed HassenStefan HeinrichRyota HiguchiDaniel HoffmanDavid HolroydDaniel HughesArpad IvaneczSatheesh IypeIsabel Jaen TorrejimenoShantanu JoglekarRobert JonesKlaus KaczirekHarsh KanhereAmbareen KausarZhanyi KeeJessica KeilsonJorg KleefJohannes KloseBrett KnowlesJun Kit KoongNagappan KumarSupreeth KunnuruPaleswan Joshi LakheyAndrea LaurenziYeong Sing LeeFelipe LeonVoon Meng LeowJean-Baptiste LequeuMickael LesurtelElisabeth LoStefan LöbElizabeth LockiePeter LodgeDolores López GarnicaVictor Lopez LopezLinda LundgrenNikolaos MachairasDhiresh MaharjanDeep MaldeGuillaume MartelJulie MartinMichele MazzolaArianeb MehrabiRicardo MemeoFlavio MilanaGeorge MolinaLeah MonetteHaluk MorgulDimitrios MorisAntonios Morsi-YeroyannisNicholas MowbrayFrancesk MulitaEdoardo Maria MuttilloMalith NandasenaPueya Rashid NashidengoArash NickkholghColin Byron NoelMasayuki OhtsukaArturs OzolinsSanjay PandanaboyanaNikolaos PararasAlessandro ParenteJune PengArkaitz Perfecto ValeroJulie PerinelKonstatinos PerivoliotisTeresa PerraPatrick PessauxNatalie PetruchGaetano PiccoloLaszlo PirosAlberto PorcuViswakumar PrabakaranRaj PrasadMikel Prieto CalvoFlorian PrimavesiEva Maria Pueyo PerizAlberto QuagliaJose M. Ramia AngelAshwin RammohanFrancisco RazionaleRicardo Robles CamposManas RoySophie RozwadowskiLuis RuffoloNatalia RuizAndrea RuzzenanteLily SaadatMohamed Amine SaidEdoardo SaladinoGabriel SalibaPer SandstromCarlo Alberto SchenaAnthony ScholerCristoph SchwartzLorenzo SerafiniPablo SerranoDeepak SharmaAali SheenVishwanath SiddagangaiahMichael SilvaSaurabh SinghAjith SiriwardenaMichal SkalskiMante SmigFaris SolimanDonzília Sousa SilvaErnesto SparrelidParthi SrinivasanMalin Sternby EilardOliver StrobelUrban StupanMiguel Angel Suarez-MunozManisekar SubramaniamTeiichi SugiuraRobert SutcliffeHilko SwankLillian TaylorPrabin Bikram ThapaCatherine TheAsara ThepbunchonchaiCaman ThieuNavneet TiwariGuido TorzilliChutwichai TovikkaiBlaz TrotovsekSavvas TsaramanidisGeorgios TsoulfasKatsuhiko UesakaGarzali UmarLucio UrbaniMichail VailasRonald van DamPeter van de BoezemStijn van LaarhovenTomas VanagasMike Van DoorenManon ViannetLuca ViganoAarathi VijayashankerCelia VillodreToshifumi WakaiAklile WorknehLi XuMasakazu YamamotoZhiying YangRobert YoungMarko Zivanovic
Source
EClinicalMedicine, Vol 59, Iss , Pp 101951- (2023)
Subject
Gallbladder cancer
Liver resection
Surgical outcomes
Cholangiocarcinoma
Medicine (General)
R5-920
Language
English
ISSN
2589-5370
Abstract
Summary: Background: Gallbladder cancer (GBC) is rare but aggressive. The extent of surgical intervention for different GBC stages is non-uniform, ranging from cholecystectomy alone to extended resections including major hepatectomy, resection of adjacent organs and routine extrahepatic bile duct resection (EBDR). Robust evidence here is lacking, however, and survival benefit poorly defined. This study assesses factors associated with recurrence-free survival (RFS), overall survival (OS) and morbidity and mortality following GBC surgery in high income countries (HIC) and low and middle income countries (LMIC). Methods: The multicentre, retrospective Operative Management of Gallbladder Cancer (OMEGA) cohort study included all patients who underwent GBC resection across 133 centres between 1st January 2010 and 31st December 2020. Regression analyses assessed factors associated with OS, RFS and morbidity. Findings: On multivariable analysis of all 3676 patients, wedge resection and segment IVb/V resection failed to improve RFS (HR 1.04 [0.84–1.29], p = 0.711 and HR 1.18 [0.95–1.46], p = 0.13 respectively) or OS (HR 0.96 [0.79–1.17], p = 0.67 and HR 1.48 [1.16–1.88], p = 0.49 respectively), while major hepatectomy was associated with worse RFS (HR 1.33 [1.02–1.74], p = 0.037) and OS (HR 1.26 [1.03–1.53], p = 0.022). Furthermore, EBDR (OR 2.86 [2.3–3.52], p