학술논문
Decreased CSF clearance and increased brain amyloid in Alzheimer’s disease
Document Type
article
Author
Source
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-9 (2022)
Subject
Language
English
ISSN
2045-8118
Abstract
Abstract Background In sporadic Alzheimer’s disease (AD), brain amyloid-beta (Aβ) deposition is believed to be a consequence of impaired Aβ clearance, but this relationship is not well established in living humans. CSF clearance, a major feature of brain glymphatic clearance (BGC), has been shown to be abnormal in AD murine models. MRI phase contrast and intrathecally delivered contrast studies have reported reduced CSF flow in AD. Using PET and tau tracer 18F-THK5117, we previously reported that the ventricular CSF clearance of the PET tracer was reduced in AD and associated with elevated brain Aβ levels. Methods In the present study, we use two PET tracers, 18F-THK5351 and 11C-PiB to estimate CSF clearance calculated from early dynamic PET frames in 9 normal controls and 15 AD participants. Results we observed that the ventricular CSF clearance measures were correlated (r = 0.66, p