학술논문
Genome-wide associations of aortic distensibility suggest causality for aortic aneurysms and brain white matter hyperintensities
Document Type
article
Author
Catherine M. Francis; Matthias E. Futschik; Jian Huang; Wenjia Bai; Muralidharan Sargurupremraj; Alexander Teumer; Monique M. B. Breteler; Enrico Petretto; Amanda S. R. Ho; Philippe Amouyel; Stefan T. Engelter; Robin Bülow; Uwe Völker; Henry Völzke; Marcus Dörr; Mohammed-Aslam Imtiaz; N. Ahmad Aziz; Valerie Lohner; James S. Ware; Stephanie Debette; Paul Elliott; Abbas Dehghan; Paul M. Matthews
Source
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Aortic distensibility is a risk factor for multiple cardiovascular events, but the genetic etiology is not well understood. Here, the authors identify genetic variants linked to aortic distensibility, highlighting mechanistic pathways and causal relationships between distensibility and both aortic aneurysms and brain small vessel disease.