부산대학교 도서관

Introduction: Epidermolysis bullosa (EB) is a rare inherited genetic skin disorder with severe skin itching and recurrent blisters and erosion. There is no effective and specific therapy for all types of EB. Objective: The aim of this study was to evaluate a topical formulation of henna (Lawsonia inermis L.) in the management of wounds and the itching sensation in patients with EB. Methods: This is a pilot single-arm clinical trial. Nine patients with recessive dystrophic EB (RDEB), with the age range of 5 to 32 years old were enrolled in the study. The patients were instructed to apply the topical 1% henna ointment once daily on two erosions and on also two sites with moderate to a severe itching sensation. The total duration of the intervention was four weeks with weekly follow-up visits. Patient global impression of improvement (PGI-I), visual analog scale (VAS), and clinical global impression of improvement (CGI-I) were used for assessing the wound healing process and itching discomfort. Results: There was a significant improvement in the skin symptoms of epidermolysis bullosa including skin redness, itching, burning, and local warmness (p-value