학술논문
Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential
Document Type
article
Author
Farheen Badrealam Khan; Shahab Uddin; Abozer Y. Elderdery; Khang Wen Goh; Long Chiau Ming; Chrismawan Ardianto; Abdul Rasheed Palakot; Irfa Anwar; Mohsina Khan; Mohammad Owais; Chih-Yang Huang; Jayasimha Rayalu Daddam; Meraj Alam Khan; Shoaib Shoaib; Md Khursheed; Sara Reshadat; Hamid Reza Khayat Kashani; Sameer Mirza; Abbas A. Khaleel; Mohammed Akli Ayoub
Source
Cells, Vol 11, Iss 22, p 3664 (2022)
Subject
Language
English
ISSN
2073-4409
Abstract
Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide. Accumulating evidences have highlighted the importance of exosomes and non-coding RNAs (ncRNAs) in cardiac physiology and pathology. It is in general consensus that exosomes and ncRNAs play a crucial role in the maintenance of normal cellular function; and interestingly it is envisaged that their potential as prospective therapeutic candidates and biomarkers are increasing rapidly. Considering all these aspects, this review provides a comprehensive overview of the recent understanding of exosomes and ncRNAs in CVDs. We provide a great deal of discussion regarding their role in the cardiovascular system, together with providing a glimpse of ideas regarding strategies exploited to harness their potential as a therapeutic intervention and prospective biomarker against CVDs. Thus, it could be envisaged that a thorough understanding of the intricacies related to exosomes and ncRNA would seemingly allow their full exploration and may lead clinical settings to become a reality in near future.