학술논문
Positive family history as a predictor for disease outcomes after radical prostatectomy for nonmetastatic prostate cancer
Document Type
article
Author
Pawel Rajwa; Fahad Quhal; David D’Andrea; Stephan Korn; Patrik Petrov; Takafumi Yanagisawa; Tatsushi Kawada; Reza Sari Motlagh; Hadi Mostafaei; Ekaterina Laukhtina; Abdulmajeed Aydh; Frederik König; Maximilian Pallauf; Benjamin Pradere; Peter Nyirády; Mohammad Abufaraj; Giancarlo Marra; Giorgio Gandaglia; Alberto Briganti; Pierre Karakiewicz; Ding-wei Ye; Martin Haydter; Piotr Chlosta; Eva Comperat; Dmitry Enikeev; Shahrokh F. Shariat
Source
Arab Journal of Urology, Pp 1-7 (2023)
Subject
Language
English
ISSN
2090598X
2090-598X
2090-598X
Abstract
ABSTRACTBackground While family history (FHx) of prostate cancer (PCa) increases the risk of PCa, comparably less is known regarding the impact of FHx on pathologic and oncologic outcomes after radical prostatectomy (RP).Methods We retrospectively reviewed our multicenter database comprising 6,041 nonmetastatic PCa patients treated with RP. Patients with a FHx of PCa in one or more first-degree relatives were considered as FHx positive. We examined the association of FHx with pathologic outcomes and biochemical recurrence (BCR) using logistic and Cox regression models, respectively.Results In total, 1,677 (28%) patients reported a FHx of PCa. Compared to patients without FHx, those with, were younger at RP (median age of 59 vs. 62 years, p