학술논문
Association between the tissue accumulation of advanced glycation end products and exercise capacity in cardiac rehabilitation patients
Document Type
article
Author
Mitsuhiro Kunimoto; Kazunori Shimada; Miho Yokoyama; Tomomi Matsubara; Tatsuro Aikawa; Shohei Ouchi; Megumi Shimizu; Kosuke Fukao; Tetsuro Miyazaki; Tomoyasu Kadoguchi; Kei Fujiwara; Abidan Abulimiti; Akio Honzawa; Miki Yamada; Akie Shimada; Taira Yamamoto; Tohru Asai; Atsushi Amano; Andries J. Smit; Hiroyuki Daida
Source
BMC Cardiovascular Disorders, Vol 20, Iss 1, Pp 1-9 (2020)
Subject
Language
English
ISSN
1471-2261
Abstract
Abstract Background Advanced glycation end products (AGEs) are associated with aging, diabetes mellitus (DM), and other chronic diseases. Recently, the accumulation of AGEs can be evaluated by skin autofluorescence (SAF). However, the relationship between SAF levels and exercise capacity in patients with cardiovascular disease (CVD) remains unclear. This study aimed to investigate the association between the tissue accumulation of AGEs and clinical characteristics, including exercise capacity, in patients with CVD. Methods We enrolled 319 consecutive CVD patients aged ≥40 years who underwent early phase II cardiac rehabilitation (CR) at our university hospital between November 2015 and September 2017. Patient background, clinical data, and the accumulation of AGEs assessed by SAF were recorded at the beginning of CR. Characteristics were compared between two patient groups divided according to the median SAF level (High SAF and Low SAF). Results The High SAF group was significantly older and exhibited a higher prevalence of DM than the Low SAF group. The sex ratio did not differ between the two groups. AGE levels showed significant negative correlations with peak oxygen uptake and ventilator efficiency (both P