학술논문
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling
Document Type
article
Author
Sebastian Scheer; Suzanne Ackloo; Tiago S. Medina; Matthieu Schapira; Fengling Li; Jennifer A. Ward; Andrew M. Lewis; Jeffrey P. Northrop; Paul L. Richardson; H. Ümit Kaniskan; Yudao Shen; Jing Liu; David Smil; David McLeod; Carlos A. Zepeda-Velazquez; Minkui Luo; Jian Jin; Dalia Barsyte-Lovejoy; Kilian V. M. Huber; Daniel D. De Carvalho; Masoud Vedadi; Colby Zaph; Peter J. Brown; Cheryl H. Arrowsmith
Source
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Protein methyltransferases (PMTs) are epigenetic regulatory enzymes with significant therapeutic relevance. Here the authors describe a collection of chemical inhibitors and antagonists to modulate most of the key methylation marks on histones H3 and H4, and use the collection to study of the role of PMTs in mouse and human T cell differentiation.