학술논문
Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies distinct proteotypes associated with patient outcomes
Document Type
article
Author
Shideh Mirhadi; Shirley Tam; Quan Li; Nadeem Moghal; Nhu-An Pham; Jiefei Tong; Brian J. Golbourn; Jonathan R. Krieger; Paul Taylor; Ming Li; Jessica Weiss; Sebastiao N. Martins-Filho; Vibha Raghavan; Yasin Mamatjan; Aafaque A. Khan; Michael Cabanero; Shingo Sakashita; Kugeng Huo; Sameer Agnihotri; Kota Ishizawa; Thomas K. Waddell; Gelareh Zadeh; Kazuhiro Yasufuku; Geoffrey Liu; Frances A. Shepherd; Michael F. Moran; Ming-Sound Tsao
Source
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
With non-small cell lung cancer (NSCLC) being the leading cause of cancer deaths worldwide, the development of targeted therapies remains crucial. Here, the generation and multi-omics characterization of 137 NSCLC patient-derived xenografts provides a resource for potential classifications and targets.