학술논문
Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci
Document Type
article
Author
Source
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-13 (2019)
Subject
Language
English
ISSN
1868-7075
1868-7083
1868-7083
Abstract
Abstract Background DNA methylation alteration extensively associates with smoking and is a plausible link between smoking and adverse health. We examined the association between epigenome-wide DNA methylation and serum cotinine levels as a proxy of nicotine exposure and smoking quantity, assessed the role of SNPs in these associations, and evaluated molecular mediation by methylation in a sample of biochemically verified current smokers (N = 310). Results DNA methylation at 50 CpG sites was associated (FDR