학술논문

Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?
Document Type
article
Source
GMS Hygiene and Infection Control, Vol 12, p Doc05 (2017)
Subject
multidrug-resistant Gram-negative bacteria
epidemiology
surveillance
reservoirs
resistance patterns
therapy
infection control measures
biocides
disinfection
agriculture
Medicine
Public aspects of medicine
RA1-1270
Microbiology
QR1-502
Language
German
English
ISSN
2196-5226
Abstract
In the past years infections caused by multidrug-resistant Gram-negative bacteria have dramatically increased in all parts of the world. This consensus paper is based on presentations, subsequent discussions and an appraisal of current literature by a panel of international experts invited by the Rudolf Schülke Stiftung, Hamburg. It deals with the epidemiology and the inherent properties of Gram-negative bacteria, elucidating the patterns of the spread of antibiotic resistance, highlighting reservoirs as well as transmission pathways and risk factors for infection, mortality, treatment and prevention options as well as the consequences of their prevalence in livestock. Following a global, One Health approach and based on the evaluation of the existing knowledge about these pathogens, this paper gives recommendations for prevention and infection control measures as well as proposals for various target groups to tackle the threats posed by Gram-negative bacteria and prevent the spread and emergence of new antibiotic resistances.