학술논문
Immunofibroblasts regulate LTα3 expression in tertiary lymphoid structures in a pathway dependent on ICOS/ICOSL interaction
Document Type
article
Author
Saba Nayar; Elena Pontarini; Joana Campos; Onorina Berardicurti; Charlotte G. Smith; Saba Asam; David H. Gardner; Serena Colafrancesco; Davide Lucchesi; Rachel Coleby; Ming-May Chung; Valentina Iannizzotto; Kelly Hunter; Simon J. Bowman; Gianluca Carlesso; Ronald Herbst; Helen M. McGettrick; Jeff Browning; Christopher D. Buckley; Benjamin A. Fisher; Michele Bombardieri; Francesca Barone
Source
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Subject
Language
English
ISSN
2399-3642
Abstract
The study suggests a link between ICOS-ICOSL signaling and LTa3 induction on T cells. LTa3 subsequently activates fibroblasts in the salivary gland, leading to formation of tertiary lymphoid tissues (TLS).