학술논문
T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles
Document Type
article
Author
Verena Turco; Kira Pfleiderer; Jessica Hunger; Natalie K. Horvat; Kianush Karimian-Jazi; Katharina Schregel; Manuel Fischer; Gianluca Brugnara; Kristine Jähne; Volker Sturm; Yannik Streibel; Duy Nguyen; Sandro Altamura; Dennis A. Agardy; Shreya S. Soni; Abdulrahman Alsasa; Theresa Bunse; Matthias Schlesner; Martina U. Muckenthaler; Ralph Weissleder; Wolfgang Wick; Sabine Heiland; Philipp Vollmuth; Martin Bendszus; Christopher B. Rodell; Michael O. Breckwoldt; Michael Platten
Source
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
Glioblastoma is a highly aggressive, and also the most common, brain tumour type in adults. Here, the authors generate a nanoparticle encapsulating the TLR7/8 agonist, R848, which induces tumour regression in mice by reprogramming myeloid cells independently of T and NK cells.