학술논문
Genomic characterization of malignant progression in neoplastic pancreatic cysts
Document Type
article
Author
Michaël Noë; Noushin Niknafs; Catherine G. Fischer; Wenzel M. Hackeng; Violeta Beleva Guthrie; Waki Hosoda; Marija Debeljak; Eniko Papp; Vilmos Adleff; James R. White; Claudio Luchini; Antonio Pea; Aldo Scarpa; Giovanni Butturini; Giuseppe Zamboni; Paola Castelli; Seung-Mo Hong; Shinichi Yachida; Nobuyoshi Hiraoka; Anthony J. Gill; Jaswinder S. Samra; G. Johan A. Offerhaus; Anne Hoorens; Joanne Verheij; Casper Jansen; N. Volkan Adsay; Wei Jiang; Jordan Winter; Jorge Albores-Saavedra; Benoit Terris; Elizabeth D. Thompson; Nicholas J. Roberts; Ralph H. Hruban; Rachel Karchin; Robert B. Scharpf; Lodewijk A. A. Brosens; Victor E. Velculescu; Laura D. Wood
Source
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Neoplastic pancreatic cysts are associated with invasive pancreatic cancer, but their origins and evolutionary relationships are unclear. Here, the authors present the evolutionary analysis of neoplastic cysts and report them as precursors of invasive pancreatic cancer, and that SMAD4/TGFBR2 alterations are likely drivers of invasion in a subset of cases.