학술논문
Neuropilin-2 mediated β-catenin signaling and survival in human gastro-intestinal cancer cell lines.
Document Type
article
Author
Source
PLoS ONE, Vol 6, Iss 10, p e23208 (2011)
Subject
Language
English
ISSN
1932-6203
Abstract
NRP-2 is a high-affinity kinase-deficient receptor for ligands belonging to the class 3 semaphorin and vascular endothelial growth factor families. NRP-2 has been detected on the surface of several types of human cancer cells, but its expression and function in gastrointestinal (GI) cancer cells remains to be determined. We sought to determine the function of NRP-2 in mediating downstream signals regulating the growth and survival of human gastrointestinal cancer cells. In human gastric cancer specimens, NRP-2 expression was detected in tumor tissues but not in adjacent normal mucosa. In CNDT 2.5 cells, shRNA mediated knockdown NRP-2 expression led to decreased migration and invasion in vitro (p