학술논문
CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer
Document Type
article
Author
Musaddeque Ahmed; Fraser Soares; Ji-Han Xia; Yue Yang; Jing Li; Haiyang Guo; Peiran Su; Yijun Tian; Hyung Joo Lee; Miranda Wang; Nayeema Akhtar; Kathleen E. Houlahan; Almudena Bosch; Stanley Zhou; Parisa Mazrooei; Junjie T. Hua; Sujun Chen; Jessica Petricca; Yong Zeng; Alastair Davies; Michael Fraser; David A. Quigley; Felix Y. Feng; Paul C. Boutros; Mathieu Lupien; Amina Zoubeidi; Liang Wang; Martin J. Walsh; Ting Wang; Shancheng Ren; Gong-Hong Wei; Housheng Hansen He
Source
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Prostate cancer risk-associated SNPs are enriched in noncoding CREs. Here the authors perform CRISPRi screens of CREs in prostate cancer cell lines to describe a causal mechanism synergistically driven by a risk SNP and DNA methylation-mediated 3D genome architecture.