학술논문
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
Document Type
article
Author
Edith Hofer; Gennady V. Roshchupkin; Hieab H. H. Adams; Maria J. Knol; Honghuang Lin; Shuo Li; Habil Zare; Shahzad Ahmad; Nicola J. Armstrong; Claudia L. Satizabal; Manon Bernard; Joshua C. Bis; Nathan A. Gillespie; Michelle Luciano; Aniket Mishra; Markus Scholz; Alexander Teumer; Rui Xia; Xueqiu Jian; Thomas H. Mosley; Yasaman Saba; Lukas Pirpamer; Stephan Seiler; James T. Becker; Owen Carmichael; Jerome I. Rotter; Bruce M. Psaty; Oscar L. Lopez; Najaf Amin; Sven J. van der Lee; Qiong Yang; Jayandra J. Himali; Pauline Maillard; Alexa S. Beiser; Charles DeCarli; Sherif Karama; Lindsay Lewis; Mat Harris; Mark E. Bastin; Ian J. Deary; A. Veronica Witte; Frauke Beyer; Markus Loeffler; Karen A. Mather; Peter R. Schofield; Anbupalam Thalamuthu; John B. Kwok; Margaret J. Wright; David Ames; Julian Trollor; Jiyang Jiang; Henry Brodaty; Wei Wen; Meike W. Vernooij; Albert Hofman; André G. Uitterlinden; Wiro J. Niessen; Katharina Wittfeld; Robin Bülow; Uwe Völker; Zdenka Pausova; G. Bruce Pike; Sophie Maingault; Fabrice Crivello; Christophe Tzourio; Philippe Amouyel; Bernard Mazoyer; Michael C. Neale; Carol E. Franz; Michael J. Lyons; Matthew S. Panizzon; Ole A. Andreassen; Anders M. Dale; Mark Logue; Katrina L. Grasby; Neda Jahanshad; Jodie N. Painter; Lucía Colodro-Conde; Janita Bralten; Derrek P. Hibar; Penelope A. Lind; Fabrizio Pizzagalli; Jason L. Stein; Paul M. Thompson; Sarah E. Medland; ENIGMA consortium; Perminder S. Sachdev; William S. Kremen; Joanna M. Wardlaw; Arno Villringer; Cornelia M. van Duijn; Hans J. Grabe; William T. Longstreth; Myriam Fornage; Tomas Paus; Stephanie Debette; M. Arfan Ikram; Helena Schmidt; Reinhold Schmidt; Sudha Seshadri
Source
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.