학술논문
Proteome effects of genome-wide single gene perturbations
Document Type
article
Author
Source
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Protein abundance is controlled at the transcriptional, translational and posttranslational levels. Here, Öztürk et al. determine proteome changes resulting from individual knockout of 3308 nonessential genes in the yeast S. pombe, infer gene functionality, and show that protein upregulation under stable transcript expression utilizes optimal codons.