학술논문
Long-term efficacy of a 2-year MRI treat-to-target strategy on disease activity and radiographic progression in patients with rheumatoid arthritis in clinical remission: 5-year follow-up of the IMAGINE-RA randomised trial
Document Type
article
Author
Merete Lund Hetland; Hanne Lindegaard; Oliver Hendricks; Niels Steen Krogh; Robin Christensen; Mikkel Østergaard; Mikael Boesen; Ellen Margrethe Hauge; Lykke Midtbøll Ørnbjerg; Daniel Glinatsi; Sabrina Mai Nielsen; Kim Hørslev-Petersen; Bo Ejbjerg; Kristian Stengaard-Pedersen; Ole Rintek Madsen; Jan Alexander Villadsen; Henrik Thomsen; Signe Møller-Bisgaard; Bente Jensen; Jakob Møllenbach Møller
Source
RMD Open, Vol 10, Iss 1 (2024)
Subject
Language
English
ISSN
2056-5933
Abstract
Objective To investigate whether a 2-year MRI treat-to-target strategy targeting the absence of osteitis combined with clinical remission, compared with a conventional treat-to-target strategy targeting clinical remission only (IMAGINE-rheumatoid arthritis (RA) trial) improves clinical and radiographic outcomes over 5 years in patients with RA in clinical remission.Methods IMAGINE-more was an observational extension study of the original 2-year IMAGINE-RA randomised trial (NCT01656278). Clinical examinations and radiographs (hands and feet) were obtained yearly. Prespecified coprimary outcomes at year 5 were Disease Activity Score in 28 joints C reactive protein (DAS28-CRP) remission rate (DAS28-CRP