학술논문
The genomic and epigenomic evolutionary history of papillary renal cell carcinomas
Document Type
article
Author
Bin Zhu; Maria Luana Poeta; Manuela Costantini; Tongwu Zhang; Jianxin Shi; Steno Sentinelli; Wei Zhao; Vincenzo Pompeo; Maurizio Cardelli; Boian S. Alexandrov; Burcak Otlu; Xing Hua; Kristine Jones; Seth Brodie; Malgorzata Ewa Dabrowska; Jorge R. Toro; Meredith Yeager; Mingyi Wang; Belynda Hicks; Ludmil B. Alexandrov; Kevin M. Brown; David C. Wedge; Stephen Chanock; Vito Michele Fazio; Michele Gallucci; Maria Teresa Landi
Source
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Many tumours are heterogenous, which calls into question whether multiple biopsies are required to accurately assess the cancer. Here, the authors show that papillary renal cell carcinoma is clonal in nature, suggesting that in this cancer one biopsy is sufficient for diagnosis and molecular analyses.