학술논문
Clonal somatic copy number altered driver events inform drug sensitivity in high-grade serous ovarian cancer
Document Type
article
Author
Filipe Correia Martins; Dominique-Laurent Couturier; Ines de Santiago; Carolin Margarethe Sauer; Maria Vias; Mihaela Angelova; Deborah Sanders; Anna Piskorz; James Hall; Karen Hosking; Anumithra Amirthanayagam; Sabina Cosulich; Larissa Carnevalli; Barry Davies; Thomas B. K. Watkins; Ionut G. Funingana; Helen Bolton; Krishnayan Haldar; John Latimer; Peter Baldwin; Robin Crawford; Matthew Eldridge; Bristi Basu; Mercedes Jimenez-Linan; Andrew W. Mcpherson; Nicholas McGranahan; Kevin Litchfield; Sohrab P. Shah; Iain McNeish; Carlos Caldas; Gerard Evan; Charles Swanton; James D. Brenton
Source
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Chromosomal instability is a major challenge to patient stratification and targeted drug development for high-grade serous ovarian carcinoma. Here we show that identification of clonal somatic copy number alterations in frequently amplified cancer genes could inform therapeutics for precision medicine.