학술논문
Visible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles
Document Type
article
Author
Source
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
To address the shortcomings in the application of bioactive peptides as drugs, incorporation of unnatural amino acids (UAAs) has been used. Here, the authors report an ionic compound-promoted C-N cleavage of alkyl pyridinium to generate alkyl radicals upon excitation by visible light, and apply it for deaminative hydroalkylation of alkenes to synthesise diverse β-alkyl substituted UAAs.