학술논문
Cross-species spill-over potential of the H9N2 bat influenza A virus
Document Type
article
Author
Rabeh El-Shesheny; John Franks; Ahmed Kandeil; Rebecca Badra; Jasmine Turner; Patrick Seiler; Bindumadhav M. Marathe; Trushar Jeevan; Lisa Kercher; Meng Hu; Yul Eum Sim; Kenrie P. Y. Hui; Michael C. W. Chan; Andrew J. Thompson; Pamela McKenzie; Elena A. Govorkova; Charles J. Russell; Peter Vogel; James C. Paulson; J. S. Malik Peiris; Robert G. Webster; Mohamed A. Ali; Ghazi Kayali; Richard J. Webby
Source
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Subject
Language
English
ISSN
2041-1723
Abstract
Abstract In 2017, a novel influenza A virus (IAV) was isolated from an Egyptian fruit bat. In contrast to other bat influenza viruses, the virus was related to avian A(H9N2) viruses and was probably the result of a bird-to-bat transmission event. To determine the cross-species spill-over potential, we biologically characterize features of A/bat/Egypt/381OP/2017(H9N2). The virus has a pH inactivation profile and neuraminidase activity similar to those of human-adapted IAVs. Despite the virus having an avian virus–like preference for α2,3 sialic acid receptors, it is unable to replicate in male mallard ducks; however, it readily infects ex-vivo human respiratory cell cultures and replicates in the lungs of female mice. A/bat/Egypt/381OP/2017 replicates in the upper respiratory tract of experimentally-infected male ferrets featuring direct-contact and airborne transmission. These data suggest that the bat A(H9N2) virus has features associated with increased risk to humans without a shift to a preference for α2,6 sialic acid receptors.