학술논문
Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson’s disease-like pathology
Document Type
article
Author
Source
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Mutations in the parkin, an ubiquitin ligase, are linked to Parkinson’s disease. Here the authors show that synaptotagmin-11 is a parkin substrate and that its upregulation affects dopamine release, triggers degeneration, and causes motor impairment.