학술논문
Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma
Document Type
article
Author
Shannon Coy; Shu Wang; Sylwia A. Stopka; Jia-Ren Lin; Clarence Yapp; Cecily C. Ritch; Lisa Salhi; Gregory J. Baker; Rumana Rashid; Gerard Baquer; Michael Regan; Prasidda Khadka; Kristina A. Cole; Jaeho Hwang; Patrick Y. Wen; Pratiti Bandopadhayay; Mariarita Santi; Thomas De Raedt; Keith L. Ligon; Nathalie Y. R. Agar; Peter K. Sorger; Mehdi Touat; Sandro Santagata
Source
Nature Communications, Vol 13, Iss 1, Pp 1-24 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
The components of the glioma immune microenvironment and their roles in promoting tumourigenesis remain poorly understood. Here, the use of single-cell RNA sequencing and multiplexed tissue-imaging in adult and pediatric high-grade gliomas reveals the activity and spatial organization of the immunomodulatory purinergic signaling pathway.