학술논문
Clinical characteristics of patients with COVID-19 harboring detectable intracellular SARS-CoV-2 RNA in peripheral blood cells
Document Type
article
Author
Hiromu Tanaka; Ho Namkoong; Shotaro Chubachi; Shinji Irie; Yoshifumi Uwamino; Ho Lee; Shuhei Azekawa; Shiro Otake; Kensuke Nakagawara; Takahiro Fukushima; Mayuko Watase; Tatsuya Kusumoto; Katsunori Masaki; Hirofumi Kamata; Makoto Ishii; Yukinori Okada; Tomomi Takano; Seiya Imoto; Ryuji Koike; Akinori Kimura; Satoru Miyano; Seishi Ogawa; Takanori Kanai; Taka-Aki Sato; Koichi Fukunaga
Source
International Journal of Infectious Diseases, Vol 135, Iss , Pp 41-44 (2023)
Subject
Language
English
ISSN
1201-9712
Abstract
Objectives: Although SARS-CoV-2 RNAemia has been reported to strongly impact patients with severe COVID-19, the clinical characteristics of patients with COVID-19 harboring detectable intracellular SARS-CoV-2 RNA remain unknown. Methods: We included adult patients who had developed COVID-19 between February and September 2020. Total white blood cells derived from the buffy coat of peripheral whole blood were used to detect SARS-CoV-2 RNA using the Illumina COVIDSeq test. We compared the clinical characteristics between patients with and without detected viral RNA (detected and undetected groups). Results: Among the 390 patients included, 17 harbored SARS-CoV-2 RNA in peripheral white blood cells. All 17 patients required oxygen support during the disease course and had higher intensive care unit admission (52.9% vs 28.9%, P = 0.035), mortality (17.7% vs 3.5%, P = 0.004), kidney dysfunction (severe, 23.5% vs 6.4%, P = 0.029), and corticosteroid treatment rates (76.5% vs 46.5%, P = 0.016) than those of patients in the undetected group. Conclusion: We propose that patients with circulating intracellular SARS-CoV-2 RNA in the peripheral blood exhibited the most severe disease course.