학술논문
MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling
Document Type
article
Author
Dario Zimmerli; Chiara S. Brambillasca; Francien Talens; Jinhyuk Bhin; Renske Linstra; Lou Romanens; Arkajyoti Bhattacharya; Stacey E. P. Joosten; Ana Moises Da Silva; Nuno Padrao; Max D. Wellenstein; Kelly Kersten; Mart de Boo; Maurits Roorda; Linda Henneman; Roebi de Bruijn; Stefano Annunziato; Eline van der Burg; Anne Paulien Drenth; Catrin Lutz; Theresa Endres; Marieke van de Ven; Martin Eilers; Lodewyk Wessels; Karin E. de Visser; Wilbert Zwart; Rudolf S. N. Fehrmann; Marcel A. T. M. van Vugt; Jos Jonkers
Source
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Tripe-negative breast cancers poorly respond to immune checkpoint inhibition therapy, due to their immune-hostile tumour microenvironment. Authors here show that the oncogene MYC plays a pivotal role in suppressing anti-tumour immunity via directly regulating the transcription of interferon signalling genes.