학술논문
The protective effect of Bergamot Polyphenolic Fraction on reno-cardiac damage induced by DOCA-salt and unilateral renal artery ligation in rats
Document Type
article
Author
Cristina Carresi; Antonio Cardamone; Anna Rita Coppoletta; Rosamaria Caminiti; Roberta Macrì; Francesca Lorenzo; Federica Scarano; Rocco Mollace; Lorenza Guarnieri; Stefano Ruga; Saverio Nucera; Vincenzo Musolino; Micaela Gliozzi; Ernesto Palma; Carolina Muscoli; Maurizio Volterrani; Vincenzo Mollace
Source
Biomedicine & Pharmacotherapy, Vol 171, Iss , Pp 116082- (2024)
Subject
Language
English
ISSN
0753-3322
Abstract
To date, the complex pathological interactions between renal and cardiovascular systems represent a real global epidemic in both developed and developing countries. In this context, renovascular hypertension (RVH) remains among the most prevalent, but also potentially reversible, risk factor for numerous reno-cardiac diseases in humans and pets. Here, we investigated the anti-inflammatory and reno-cardiac protective effects of a polyphenol-rich fraction of bergamot (BPF) in an experimental model of hypertension induced by unilateral renal artery ligation. Adult male Wistar rats underwent unilateral renal artery ligation and treatment with deoxycorticosterone acetate (DOCA) (20 mg/kg, s.c.), twice a week for a period of 4 weeks, and 1% sodium chloride (NaCl) water (n = 10). A subgroup of hypertensive rats received BPF (100 mg/kg/day for 28 consecutive days, n = 10) by gavage. Another group of animals was treated with a sub-cutaneous injection of vehicle (that served as control, n = 8). Unilateral renal artery ligation followed by treatment with DOCA and 1% NaCl water resulted in a significant increase in mean arterial blood pressure (MAP; p