학술논문
RSPO3 is important for trabecular bone and fracture risk in mice and humans
Document Type
article
Author
Karin H. Nilsson; Petra Henning; Maha El Shahawy; Maria Nethander; Thomas Levin Andersen; Charlotte Ejersted; Jianyao Wu; Karin L. Gustafsson; Antti Koskela; Juha Tuukkanen; Pedro P. C. Souza; Jan Tuckermann; Mattias Lorentzon; Linda Engström Ruud; Terho Lehtimäki; Jon H. Tobias; Sirui Zhou; Ulf H. Lerner; J. Brent Richards; Sofia Movérare-Skrtic; Claes Ohlsson
Source
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Genetic association signals for fractures have been reported at the RSPO3 locus, but the causal gene and the underlying mechanism are unknown. Here, the authors show that RSPO3 exerts an important role for vertebral trabecular bone mass and bone strength in mice and fracture risk in humans.