학술논문
Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody
Document Type
article
Author
Martina Geiger; Kay-Gunnar Stubenrauch; Johannes Sam; Wolfgang F. Richter; Gregor Jordan; Jan Eckmann; Carina Hage; Valeria Nicolini; Anne Freimoser-Grundschober; Mirko Ritter; Matthias E. Lauer; Henning Stahlberg; Philippe Ringler; Jigar Patel; Eric Sullivan; Sandra Grau-Richards; Stefan Endres; Sebastian Kobold; Pablo Umaña; Peter Brünker; Christian Klein
Source
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
The clinical application of T cell bispecific antibodies (TCBs) is often limited by the lack of tumour-specific antigens. In this study, the authors present a strategy to increase TCB tumour-selectivity by adding an anti-CD3 moiety that can be specifically activated by tumor specific proteases in the tumor microenvironment.