학술논문
Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
Document Type
article
Author
Ching-Ti Liu; Keri L Monda; Kira C Taylor; Leslie Lange; Ellen W Demerath; Walter Palmas; Mary K Wojczynski; Jaclyn C Ellis; Mara Z Vitolins; Simin Liu; George J Papanicolaou; Marguerite R Irvin; Luting Xue; Paula J Griffin; Michael A Nalls; Adebowale Adeyemo; Jiankang Liu; Guo Li; Edward A Ruiz-Narvaez; Wei-Min Chen; Fang Chen; Brian E Henderson; Robert C Millikan; Christine B Ambrosone; Sara S Strom; Xiuqing Guo; Jeanette S Andrews; Yan V Sun; Thomas H Mosley; Lisa R Yanek; Daniel Shriner; Talin Haritunians; Jerome I Rotter; Elizabeth K Speliotes; Megan Smith; Lynn Rosenberg; Josyf Mychaleckyj; Uma Nayak; Ida Spruill; W Timothy Garvey; Curtis Pettaway; Sarah Nyante; Elisa V Bandera; Angela F Britton; Alan B Zonderman; Laura J Rasmussen-Torvik; Yii-Der Ida Chen; Jingzhong Ding; Kurt Lohman; Stephen B Kritchevsky; Wei Zhao; Patricia A Peyser; Sharon L R Kardia; Edmond Kabagambe; Ulrich Broeckel; Guanjie Chen; Jie Zhou; Sylvia Wassertheil-Smoller; Marian L Neuhouser; Evadnie Rampersaud; Bruce Psaty; Charles Kooperberg; Joann E Manson; Lewis H Kuller; Heather M Ochs-Balcom; Karen C Johnson; Lara Sucheston; Jose M Ordovas; Julie R Palmer; Christopher A Haiman; Barbara McKnight; Barbara V Howard; Diane M Becker; Lawrence F Bielak; Yongmei Liu; Matthew A Allison; Struan F A Grant; Gregory L Burke; Sanjay R Patel; Pamela J Schreiner; Ingrid B Borecki; Michele K Evans; Herman Taylor; Michele M Sale; Virginia Howard; Christopher S Carlson; Charles N Rotimi; Mary Cushman; Tamara B Harris; Alexander P Reiner; L Adrienne Cupples; Kari E North; Caroline S Fox
Source
PLoS Genetics, Vol 9, Iss 8, p e1003681 (2013)
Subject
Language
English
ISSN
1553-7390
1553-7404
1553-7404
Abstract
Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide association study (GWAS) of fat distribution among those of predominantly African ancestry (AA). We performed GWAS of WC and WHR, adjusted and unadjusted for BMI, in up to 33,591 and 27,350 AA individuals, respectively. We identified loci associated with fat distribution in AA individuals using meta-analyses of GWA results for WC and WHR (stage 1). Overall, 25 SNPs with single genomic control (GC)-corrected p-values