학술논문
Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy
Document Type
article
Author
Charles P. Couturier; Shamini Ayyadhury; Phuong U. Le; Javad Nadaf; Jean Monlong; Gabriele Riva; Redouane Allache; Salma Baig; Xiaohua Yan; Mathieu Bourgey; Changseok Lee; Yu Chang David Wang; V. Wee Yong; Marie-Christine Guiot; Hamed Najafabadi; Bratislav Misic; Jack Antel; Guillaume Bourque; Jiannis Ragoussis; Kevin Petrecca
Source
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Glioblastoma is thought to arise from neural stem cells. Here, to investigate this, the authors use single-cell RNA-sequencing to compare glioblastoma to the fetal human brain, and find a similarity between glial progenitor cells and a subpopulation of glioblastoma cells.