학술논문
Low‐density lipoprotein cholesterol, erythrocyte, and platelet in heart failure with preserved ejection fraction
Document Type
article
Author
Masamichi Yano; Masami Nishino; Shodai Kawanami; Kohei Ukita; Akito Kawamura; Koji Yasumoto; Masaki Tsuda; Naotaka Okamoto; Yasuharu Matsunaga‐Lee; Yasuyuki Egami; Takahisa Yamada; Yoshio Yasumura; Masahiro Seo; Takaharu Hayashi; Akito Nakagawa; Yusuke Nakagawa; Shunsuke Tamaki; Yohei Sotomi; Daisaku Nakatani; Shungo Hikoso; Yasushi Sakata
Source
ESC Heart Failure, Vol 11, Iss 3, Pp 1758-1766 (2024)
Subject
Language
English
ISSN
2055-5822
Abstract
Abstract Aims Low‐density lipoprotein cholesterol (LDL‐C), anaemia and low platelets have been associated with worse clinical outcomes in heart failure patients. We investigated the relationship between the combination of these three components and clinical outcome in patients with heart failure with preserved ejection fraction (HFpEF). Methods and results We examined the data of 1021 patients with HFpEF hospitalized with acute decompensated heart failure (HF) from the PURSUIT‐HFpEF registry, a prospective, multicenter observational study. The enrolled patients were classified into four groups by an LEP (LDL‐C, Erythrocyte, and Platelet) score of 0 to 3 points, with 1 point each for LDL‐C, erythrocyte and platelet values less than the cut‐off values as calculated by receiver operating characteristic curve analysis. The endpoint, a composite of all‐cause death and HF readmission, was evaluated among the four groups. Median follow‐up duration was 579 [300, 978] days. Risk of the composite endpoint significantly differed among the four groups (P