학술논문
Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure
Document Type
article
Author
Michael G. Levin; Noah L. Tsao; Pankhuri Singhal; Chang Liu; Ha My T. Vy; Ishan Paranjpe; Joshua D. Backman; Tiffany R. Bellomo; William P. Bone; Kiran J. Biddinger; Qin Hui; Ozan Dikilitas; Benjamin A. Satterfield; Yifan Yang; Michael P. Morley; Yuki Bradford; Megan Burke; Nosheen Reza; Brian Charest; Regeneron Genetics Center; Renae L. Judy; Megan J. Puckelwartz; Hakon Hakonarson; Atlas Khan; Leah C. Kottyan; Iftikhar Kullo; Yuan Luo; Elizabeth M. McNally; Laura J. Rasmussen-Torvik; Sharlene M. Day; Ron Do; Lawrence S. Phillips; Patrick T. Ellinor; Girish N. Nadkarni; Marylyn D. Ritchie; Zoltan Arany; Thomas P. Cappola; Kenneth B. Margulies; Krishna G. Aragam; Christopher M. Haggerty; Jacob Joseph; Yan V. Sun; Benjamin F. Voight; Scott M. Damrauer
Source
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Heart failure is a major cause of cardiovascular morbidity and mortality. Here, the authors report results of a genome-wide association study meta-analysis, characterizing the role of common genetic variants in heart failure, finding overlap with common cardiovascular risk factors and imaging measures of cardiac structure/function.