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The genetic architecture of multimodal human brain age
Document Type
article
Author
Junhao Wen; Bingxin Zhao; Zhijian Yang; Guray Erus; Ioanna Skampardoni; Elizabeth Mamourian; Yuhan Cui; Gyujoon Hwang; Jingxuan Bao; Aleix Boquet-Pujadas; Zhen Zhou; Yogasudha Veturi; Marylyn D. Ritchie; Haochang Shou; Paul M. Thompson; Li Shen; Arthur W. Toga; Christos Davatzikos
Source
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Subject
Science
Language
English
ISSN
2041-1723
Abstract
Abstract The complex biological mechanisms underlying human brain aging remain incompletely understood. This study investigated the genetic architecture of three brain age gaps (BAG) derived from gray matter volume (GM-BAG), white matter microstructure (WM-BAG), and functional connectivity (FC-BAG). We identified sixteen genomic loci that reached genome-wide significance (P-value

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