부산대학교 도서관

Background: pulmonary hypertension is a serious problem in newborns, which is associated with increased pulmonary vascular resistance, leading to right-to-left extrapulmonary shunt and impaired lung oxygenation and severe hypoxemia in the neonatal period. The purpose of this study was to evaluate the effect of oral Sildenafil with intravenous Milrinone on the treatment of pulmonary hypertension in newborns.Methods: The statistical population of this study consisted of all term and late preterm neonates admitted to NICU wards of Afzalipour Hospital in Kerman. A total of 80 neonates were included and divided into the intervention group (intravenous Milrinone with oral Sildenafil), and control group (intravenous Milrinone alone). The related criteria for increasing pulmonary artery pressure, including mean pulmonary artery pressure (mean PAP), Tricuspid valve regurgitation (TR), pulmonary artery diameter (PAD) and right ventricular systolic function by measuring TAPSE (Tricuspid annular presystolic excursion) were assessed by echocardiography in the first 24hours after birth and 72 hours after the intervention in all patients. Data analysis was done through SPSS24 software.Results: The mechanical ventilation time in the group treated with oral Sildenafil (2.5 days) was significantly (p