학술논문
Predictors of renal damage in systemic lupus erythematous patients: data from a multiethnic, multinational Latin American lupus cohort (GLADEL)
Document Type
article
Author
Daniel Wojdyla; Guillermo J Pons-Estel; Bernardo A Pons-Estel; Graciela S Alarcón; Ignacio Garcia de la Torre; Rosana Quintana; Mercedes A Garcia; Veronica Saurit; Emilia I Sato; Eloisa Bonfa; Enrique R Soriano; Guillermina B Harvey; Loreto Massardo; Cristina Reátegui-Sokolova; Gloria Vasquez; Manuel F Ugarte-Gil; Rosa M Serrano-Morales; Mónica P Sacnun; Luis J Catoggio; Alejandro Alvarellos; Francisco Caeiro; Guillermo A Berbotto; Eduardo Ferreira Borba Neto; Ana Carolina de Oliveira e Silva Montandon; Nilzio A Da Silva; Fernando Cavalcanti; Marlene Guibert-Toledano; Gil A Reyes-Llerena; Oscar J Neira; Mario H Cardiel; Leonor A Barile-Fabris; Mary-Carmen Amigo; Luis H Silveira; Margarita Portela-Hernández; María Inés Segami; Rosa Chacón-Diaz; María H Esteva-Spinetti
Source
RMD Open, Vol 6, Iss 3 (2020)
Subject
Language
English
ISSN
2056-5933
Abstract
Aim A decrease in proteinuria has been considered protective from renal damage in lupus nephritis (LN), but a cut-off point has yet to be established. The aim of this study was to identify the predictors of renal damage in patients with LN and to determine the best cut-off point for a decrease in proteinuria.Methods We included patients with LN defined clinically or histologically. Possible predictors of renal damage at the time of LN diagnosis were examined: proteinuria, low complement, anti-double-stranded DNA antibodies, red cell casts, creatinine level, hypertension, renal activity (assessed by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)), prednisone dose, immunosuppressive drugs and antimalarial use. Sociodemographic variables were included at baseline. Proteinuria was assessed at baseline and at 12 months, to determine if early response (proteinuria