학술논문
Brain metastatic outgrowth and osimertinib resistance are potentiated by RhoA in EGFR-mutant lung cancer
Document Type
article
Author
Sally J. Adua; Anna Arnal-Estapé; Minghui Zhao; Bowen Qi; Zongzhi Z. Liu; Carolyn Kravitz; Heather Hulme; Nicole Strittmatter; Francesc López-Giráldez; Sampada Chande; Alexandra E. Albert; Mary-Ann Melnick; Bomiao Hu; Katerina Politi; Veronica Chiang; Nicola Colclough; Richard J. A. Goodwin; Darren Cross; Paul Smith; Don X. Nguyen
Source
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
While EGFR-targeted therapies have clinical benefit, drug-resistant brain metastases present a major obstacle. Here, the authors identify a genetic signature in brain metastatic lesions associated with osimertinib resistance and find RhoA to have an important role in the resulting phenotype.