학술논문
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function
Document Type
article
Author
Annah B. Wyss; Tamar Sofer; Mi Kyeong Lee; Natalie Terzikhan; Jennifer N. Nguyen; Lies Lahousse; Jeanne C. Latourelle; Albert Vernon Smith; Traci M. Bartz; Mary F. Feitosa; Wei Gao; Tarunveer S. Ahluwalia; Wenbo Tang; Christopher Oldmeadow; Qing Duan; Kim de Jong; Mary K. Wojczynski; Xin-Qun Wang; Raymond Noordam; Fernando Pires Hartwig; Victoria E. Jackson; Tianyuan Wang; Ma’en Obeidat; Brian D. Hobbs; Tianxiao Huan; Hongsheng Gui; Margaret M. Parker; Donglei Hu; Lauren S. Mogil; Gleb Kichaev; Jianping Jin; Mariaelisa Graff; Tamara B. Harris; Ravi Kalhan; Susan R. Heckbert; Lavinia Paternoster; Kristin M. Burkart; Yongmei Liu; Elizabeth G. Holliday; James G. Wilson; Judith M. Vonk; Jason L. Sanders; R. Graham Barr; Renée de Mutsert; Ana Maria Baptista Menezes; Hieab H. H. Adams; Maarten van den Berge; Roby Joehanes; Albert M. Levin; Jennifer Liberto; Lenore J. Launer; Alanna C. Morrison; Colleen M. Sitlani; Juan C. Celedón; Stephen B. Kritchevsky; Rodney J. Scott; Kaare Christensen; Jerome I. Rotter; Tobias N. Bonten; Fernando César Wehrmeister; Yohan Bossé; Shujie Xiao; Sam Oh; Nora Franceschini; Jennifer A. Brody; Robert C. Kaplan; Kurt Lohman; Mark McEvoy; Michael A. Province; Frits R. Rosendaal; Kent D. Taylor; David C. Nickle; L. Keoki Williams; Esteban G. Burchard; Heather E. Wheeler; Don D. Sin; Vilmundur Gudnason; Kari E. North; Myriam Fornage; Bruce M. Psaty; Richard H. Myers; George O’Connor; Torben Hansen; Cathy C. Laurie; Patricia A. Cassano; Joohon Sung; Woo Jin Kim; John R. Attia; Leslie Lange; H. Marike Boezen; Bharat Thyagarajan; Stephen S. Rich; Dennis O. Mook-Kanamori; Bernardo Lessa Horta; André G. Uitterlinden; Hae Kyung Im; Michael H. Cho; Guy G. Brusselle; Sina A. Gharib; Josée Dupuis; Ani Manichaikul; Stephanie J. London
Source
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Pulmonary function is influenced by environmental factors, lifestyle, and genetics. Here, in a multiethnic GWAS meta-analysis for pulmonary function traits, the authors identify over 50 additional genetic loci, a subset of which are specific for European, African, Asian, or Hispanic/Latino ancestry.