학술논문
CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits
Document Type
article
Author
Aurélien Macé; Marcus A. Tuke; Patrick Deelen; Kati Kristiansson; Hannele Mattsson; Margit Nõukas; Yadav Sapkota; Ursula Schick; Eleonora Porcu; Sina Rüeger; Aaron F. McDaid; David Porteous; Thomas W. Winkler; Erika Salvi; Nick Shrine; Xueping Liu; Wei Q. Ang; Weihua Zhang; Mary F. Feitosa; Cristina Venturini; Peter J. van der Most; Anders Rosengren; Andrew R. Wood; Robin N. Beaumont; Samuel E. Jones; Katherine S. Ruth; Hanieh Yaghootkar; Jessica Tyrrell; Aki S. Havulinna; Harmen Boers; Reedik Mägi; Jennifer Kriebel; Martina Müller-Nurasyid; Markus Perola; Markku Nieminen; Marja-Liisa Lokki; Mika Kähönen; Jorma S. Viikari; Frank Geller; Jari Lahti; Aarno Palotie; Päivikki Koponen; Annamari Lundqvist; Harri Rissanen; Erwin P. Bottinger; Saima Afaq; Mary K. Wojczynski; Petra Lenzini; Ilja M. Nolte; Thomas Sparsø; Nicole Schupf; Kaare Christensen; Thomas T. Perls; Anne B. Newman; Thomas Werge; Harold Snieder; Timothy D. Spector; John C. Chambers; Seppo Koskinen; Mads Melbye; Olli T. Raitakari; Terho Lehtimäki; Martin D. Tobin; Louise V. Wain; Juha Sinisalo; Annette Peters; Thomas Meitinger; Nicholas G. Martin; Naomi R. Wray; Grant W. Montgomery; Sarah E. Medland; Morris A. Swertz; Erkki Vartiainen; Katja Borodulin; Satu Männistö; Anna Murray; Murielle Bochud; Sébastien Jacquemont; Fernando Rivadeneira; Thomas F. Hansen; Albertine J. Oldehinkel; Massimo Mangino; Michael A. Province; Panos Deloukas; Jaspal S. Kooner; Rachel M. Freathy; Craig Pennell; Bjarke Feenstra; David P. Strachan; Guillaume Lettre; Joel Hirschhorn; Daniele Cusi; Iris M. Heid; Caroline Hayward; Katrin Männik; Jacques S. Beckmann; Ruth J. F. Loos; Dale R. Nyholt; Andres Metspalu; Johan G. Eriksson; Michael N. Weedon; Veikko Salomaa; Lude Franke; Alexandre Reymond; Timothy M. Frayling; Zoltán Kutalik
Source
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Subject
Language
English
ISSN
2041-1723
Abstract
Individual SNPs have small effects on anthropometric traits, yet the impact of CNVs has remained largely unknown. Here, Kutalik and co-workers perform a large-scale genome-wide meta-analysis of structural variation and find rare CNVs associated with height, weight and BMI with large effect sizes.