학술논문
Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women
Document Type
article
Author
Garan Jones; Katerina Trajanoska; Adam J. Santanasto; Najada Stringa; Chia-Ling Kuo; Janice L. Atkins; Joshua R. Lewis; ThuyVy Duong; Shengjun Hong; Mary L. Biggs; Jian’an Luan; Chloe Sarnowski; Kathryn L. Lunetta; Toshiko Tanaka; Mary K. Wojczynski; Ryan Cvejkus; Maria Nethander; Sahar Ghasemi; Jingyun Yang; M. Carola Zillikens; Stefan Walter; Kamil Sicinski; Erika Kague; Cheryl L. Ackert-Bicknell; Dan E. Arking; B. Gwen Windham; Eric Boerwinkle; Megan L. Grove; Misa Graff; Dominik Spira; Ilja Demuth; Nathalie van der Velde; Lisette C. P. G. M. de Groot; Bruce M. Psaty; Michelle C. Odden; Alison E. Fohner; Claudia Langenberg; Nicholas J. Wareham; Stefania Bandinelli; Natasja M. van Schoor; Martijn Huisman; Qihua Tan; Joseph Zmuda; Dan Mellström; Magnus Karlsson; David A. Bennett; Aron S. Buchman; Philip L. De Jager; Andre G. Uitterlinden; Uwe Völker; Thomas Kocher; Alexander Teumer; Leocadio Rodriguéz-Mañas; Francisco J. García; José A. Carnicero; Pamela Herd; Lars Bertram; Claes Ohlsson; Joanne M. Murabito; David Melzer; George A. Kuchel; Luigi Ferrucci; David Karasik; Fernando Rivadeneira; Douglas P. Kiel; Luke C. Pilling
Source
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Muscle weakness has been associated with morbidity and mortality in older people. Here, the authors have investigated this trait further by performing a genome-wide meta-analysis of grip strength and Mendelian randomization to discover causal relationships between muscle weakness and other diseases.