학술논문
Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer
Document Type
article
Author
Stefano Annunziato; Julian R. de Ruiter; Linda Henneman; Chiara S. Brambillasca; Catrin Lutz; François Vaillant; Federica Ferrante; Anne Paulien Drenth; Eline van der Burg; Bjørn Siteur; Bas van Gerwen; Roebi de Bruijn; Martine H. van Miltenburg; Ivo J. Huijbers; Marieke van de Ven; Jane E. Visvader; Geoffrey J. Lindeman; Lodewyk F. A. Wessels; Jos Jonkers
Source
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
It is difficult to identify cancer driver genes in cancers, for instance BRCA1 mutated breast cancer, that are characterised by large scale genomic alterations. Here, the authors develop genetically engineered mouse models of BRCA1-deficient breast cancer that allow highthroughput in vivo perturbation of candidate driver genes, validating drivers Myc, Met, Pten and Rb1, and identifying MCL1 as a collaborating driver whose targeting can impact efficacy of PARP inhibition.