학술논문
The role of environmental stress and DNA methylation in the longitudinal course of bipolar disorder
Document Type
article
Author
Ashley L. Comes; Darina Czamara; Kristina Adorjan; Heike Anderson-Schmidt; Till F. M. Andlauer; Monika Budde; Katrin Gade; Maria Hake; Janos L. Kalman; Sergi Papiol; Daniela Reich-Erkelenz; Farah Klöhn-Saghatolislam; Sabrina K. Schaupp; Eva C. Schulte; Fanny Senner; Georg Juckel; Max Schmauß; Jörg Zimmermann; Jens Reimer; Eva Reininghaus; Ion-George Anghelescu; Carsten Konrad; Andreas Thiel; Christian Figge; Martin von Hagen; Manfred Koller; Detlef E. Dietrich; Sebastian Stierl; Harald Scherk; Stephanie H. Witt; Sugirthan Sivalingam; Franziska Degenhardt; Andreas J. Forstner; Marcella Rietschel; Markus M. Nöthen; Jens Wiltfang; Peter Falkai; Thomas G. Schulze; Urs Heilbronner
Source
International Journal of Bipolar Disorders, Vol 8, Iss 1, Pp 1-12 (2020)
Subject
Language
English
ISSN
2194-7511
Abstract
Abstract Background Stressful life events influence the course of affective disorders, however, the mechanisms by which they bring about phenotypic change are not entirely known. Methods We explored the role of DNA methylation in response to recent stressful life events in a cohort of bipolar patients from the longitudinal PsyCourse study (n = 96). Peripheral blood DNA methylomes were profiled at two time points for over 850,000 methylation sites. The association between impact ratings of stressful life events and DNA methylation was assessed, first by interrogating methylation sites in the vicinity of candidate genes previously implicated in the stress response and, second, by conducting an exploratory epigenome-wide association analysis. Third, the association between epigenetic aging and change in stress and symptom measures over time was investigated. Results Investigation of methylation signatures over time revealed just over half of the CpG sites tested had an absolute difference in methylation of at least 1% over a 1-year period. Although not a single CpG site withstood correction for multiple testing, methylation at one site (cg15212455) was suggestively associated with stressful life events (p