학술논문
Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk
Document Type
article
Author
Jayaram Vijayakrishnan; Maoxiang Qian; James B. Studd; Wenjian Yang; Ben Kinnersley; Philip J. Law; Peter Broderick; Elizabeth A. Raetz; James Allan; Ching-Hon Pui; Ajay Vora; William E. Evans; Anthony Moorman; Allen Yeoh; Wentao Yang; Chunliang Li; Claus R. Bartram; Charles G. Mullighan; Martin Zimmerman; Stephen P. Hunger; Martin Schrappe; Mary V. Relling; Martin Stanulla; Mignon L. Loh; Richard S. Houlston; Jun J. Yang
Source
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
B-cell acute lymphoblastic leukaemia (B-ALL) is a common childhood cancer. Here, the authors conducted a meta-analysis with four genome-wide association studies, totalling 5,321 cases and 16,666 controls of European descent, identifying B-ALL risk loci, whose integration with epigenomic profiling indicates cell-cycle and B-cell development deregulation as central mechanisms in B-ALL susceptibility, often in a subtype-specific fashion.