학술논문
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia
Document Type
article
Author
Jayaram Vijayakrishnan; James Studd; Peter Broderick; Ben Kinnersley; Amy Holroyd; Philip J. Law; Rajiv Kumar; James M. Allan; Christine J. Harrison; Anthony V. Moorman; Ajay Vora; Eve Roman; Sivaramakrishna Rachakonda; Sally E. Kinsey; Eamonn Sheridan; Pamela D. Thompson; Julie A. Irving; Rolf Koehler; Per Hoffmann; Markus M. Nöthen; Stefanie Heilmann-Heimbach; Karl-Heinz Jöckel; Douglas F. Easton; Paul D. P. Pharaoh; Alison M. Dunning; Julian Peto; Frederico Canzian; Anthony Swerdlow; Rosalind A. Eeles; ZSofia Kote-Jarai; Kenneth Muir; Nora Pashayan; The PRACTICAL Consortium; Mel Greaves; Martin Zimmerman; Claus R. Bartram; Martin Schrappe; Martin Stanulla; Kari Hemminki; Richard S. Houlston
Source
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
While GWAS have uncovered susceptibility loci for B-cell precursor acute lymphoblastic leukemia (BCP-ALL), much of the heritable risk remains undiscovered. Here, the authors perform a meta-analysis of two existing BCP-ALL GWAS together with an unpublished GWAS to identify risk loci at 8q24.21 and 2q22.3.