학술논문
Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia
Document Type
article
Author
Wei-Yu Lin; Sarah E. Fordham; Nicola Sunter; Claire Elstob; Thahira Rahman; Elaine Willmore; Colin Shepherd; Gordon Strathdee; Tryfonia Mainou-Fowler; Rachel Piddock; Hannah Mearns; Timothy Barrow; Richard S. Houlston; Helen Marr; Jonathan Wallis; Geoffrey Summerfield; Scott Marshall; Andrew Pettitt; Christopher Pepper; Christopher Fegan; Francesco Forconi; Martin J. S. Dyer; Sandrine Jayne; April Sellors; Anna Schuh; Pauline Robbe; David Oscier; James Bailey; Syed Rais; Alison Bentley; Lynn Cawkwell; Paul Evans; Peter Hillmen; Guy Pratt; David J. Allsup; James M. Allan
Source
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
The clinical course of chronic lymphocytic leukaemia (CLL) is variable and difficult to predict. Here, the authors conduct a genome wide association study meta-analysis for time to first treatment in CLL patients and report two loci associating with progressive disease.